All this just my non-MD opinion! I have not had any problems with it, and always take on an empty stomach. I would assume you are on blood thinners so nattokinase may not be a great fit or serrapeptase if NOT on blood thinners, they IMO, would be helpful. I would NOT recommend supplementing calcium, but taking at least 5,000iu of D3 daily your multi should contain enough B-complex. I admit, I am not a fan of MDs these days, most are Big Pharma tools. If anyone has any suggestions toward a better plan I'm all ears. Where is it located? Natto is rich in protein, vitamins, and minerals, but most of the foods health benefits are tied to its powerful nattokinase enzyme. Copyright 2023 Dr. John Day, LLC. What happens if I overdose? Hope they help! As the Japanese are the longest-lived people on this planet, could it be the natto? Manually release pressure cooker steam as soon as cooking completed, 9. Add drained soybeans, beluga, barley and diced sweet potatoes to inner bowl, 5. I also take Qucertin, ubiniquol and digestive enzymes and the usual multi cal/mag D, B complex. Thanks so much Kat. I use Serra-Rx brand serrapeptase Dr's Best might even be better It is considered best to take Nattokinase after dinner or before sleep since thrombus is more likely to be produced during the mid-night to early morning hours. I'm very positive about this knock on wood! If anything, maybe switch off every few weeks or a month at a time. Stent in LAD. Nattokinase is known to dissolve clots in cell culture. There's some early evidence that nattokinase may have benefits for heart and artery health. However, this medicine will not work for colds, flu, or other virus infections. Blood clots and bleeding may cause serious disability or even death. In the meantime, after talking with my local pharmacist, he suggested I try a quality Nattokinase (DaVinci Labs). It goes up to 175/64, and I that's not good. i was wondering if i could have his/her name & contact info. I don't feel dizzy but sometimes I feel lightheaded. It comes and goes. It won't taste good at all. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Okay good points, thanks. The quantity required for each batch is only 0.12g, so you need a set of jewelers scales that can weigh to 3 decimal points of a gram. I take natto miso which was in supermarkets in Hawaii. (Not that I would.) Interesting!! thx! Thank you for your newsletter; it is always so informative. About 300-times stronger than serrapeptase, an enzyme extracted from silkworms. See an acupuncturist, DC, and reflexologist routinely. That mix of ingredients has an O-3 to O-6 ratio of 1.0 to 0.9. Oops! Then it started going very low, and I was having the same problem again. I am also considering drinking a small amount of DMSO with juice but with the enzymes might be a little much 3. I and this vaccine also has its issues. Glenn, I don't have a naturopath I do my own research. I am not a MD, so just my opinions. Do you have a CURRENT DVT?? After the Afib diagnosis I was told to stop the Plavix and prescribed Eliquis. 13. Stir vigorously with chopsticks to generate sticky strands containing Park S, Kim CJ, Ha KC, et al. IMO, cholesterol problems are related to INFLAMMATION, far more than cholesterol levels unless those levels are very high. Because nattokinase can dissolve blood clots, people taking blood thinner medication may be at a higher risk of bleeding.. The rest of my blood tests are ok, and I actually git a CT scan after the 1st vaccine and all was fine. GL to you both! I agree though that LK is the winner of them all, if I had to limit to one. That made my pressure after a time, very low. Thank you. Look into lumbrokinase, it does not have the potential bleeding side effects that nattokinase and serrapeptase have, serrapeptase much less that nattokinase and may help you to knock out mini-clots if they form. Hodis HN, Mack WJ, Meiselman HJ, et al. What brand of lumbrokinase do you recommend? I believe he is knowledgeable about enzymes, not sure if he recommends one of MY favorites, chlorine dioxide solution (CDS). Wire the Zio. Natto is a traditional dish in Japan. If you look any younger you will start looking like a very good looking teenager. I take 100mg Nattokinase and 80,000 of Serapeptase on empty stomach. I would check in with a naturopath, if you are able as IMO, you are taking in a LOT of blood thinning supplements daily perhaps too many. It also appears to dissolve spike protein in cell culture, but, then, it's a kinase, and dissolving proteins is what kinases do, and this is a subtilisin family serine protease. Currently on 10 mg xarelto for a DVT in left leg. I am now 75. Thus, we really dont have adequate proof yet that nattokinase lowers cholesterol. I know it is boring, but remember, I am not a Doc and do not offer medical advice but if it were me, I'd congratulate myself on that zero Calcium CT score!! Fermented soybeans such as natto contain Vitamin PQQ, which is very important for the skin.PQQ in human tissues is derived mainly from diet.4. Natto contains nattokinase, a natural blood thinner, and is also off the charts in vitamin K2. BTW: If choosing only between horse chestnut and nattokinase, I would take the nattokinase buy the NK-SD form, it is far superior. I bet he says NO. Thus, to get nattokinase, you can either get it naturally from eating natto or in a supplement extract form called nattokinase. Krishnan Medical Association SC. Response and effectiveness. I am hoping you might be able to tell me if taking 60,000 total FU (of a combo) nattokinase and serrepeptase is okay to do (2 in morning 2 later in afternoon) along with a 325mg asprin? Both ops were a success. IF you really mean natto, not nattokinase, that would be even more likely to be rendered useless. I think taking the DE right after the natto (you meant nattokinase?) I was not clear and there is no EDIT button! I have tried high dose Serrapeptase (250iu) with some success with surrounding vein inflammation. Allergol Int 2022;71(1):153-4. I have been also taking Serrapeptase with the Lumbrokinase daily, 40000 to 80000 daily. This thread has been so helpful and it seems like SK would be my best option. Any cause for concern, or just lower the dosage of the synthetic E ? I wish I could be of help to you you have a lot going on, and my level of expertise is simply not adequate to advise you you need a great cardiologist and a great naturopathic MD (NMD), probably also consult with a vascular surgeon and lipid specialist. I buy the natto spores (b.subtilis natto) online. . I recommend buying Devil's claw and bromelain individually ( I use Swansons or Ebay) and adding 40-80,000 spu serrapeptase to that mix, empty stomach then you save a ton get a stronger dose of both the DC and Brom, and don't get the ginger and add a great anti-inflammatory and healer in serrapeptase. The reason why I now buy it from a local Asian grocery store is that by the time online natto arrived at my house the ice was always melted and they charge more than my local Asian grocery store. Fortunately, studies show that when it comes to bleeding, natto and nattokinase are very safe. The capsules help to protect the contents from the digestive process so that as many of the enzymes can get to where they need to go in the body. Whether you get nattokinase from eating natto or from taking a supplement, nattokinase thins your blood many different ways. If you are taking this medication once daily, it is usually taken right before bedtime.. Information on this website is not intended to diagnose or treat any condition. Cook under maximum pressure for 1 hour, 7. If you have low blood pressure or take medication to lower your blood pressure, make sure to talk to your doctor before taking nattokinase., While nattokinases blood clot-fighting abilities may prevent deep vein thrombosis, it shouldnt be used as a treatment without a doctors supervision. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Biol Pharm Bull 1995;18:1387-91. View abstract. 7 Molasses 10.00g $0.05, Consumable Quantity and Batch Cost 700g $3.22, Daily Consumption Rate and Cost 100g $0.46, Preparation I've always been a little concerned about elevated hematocrit, but with exercise and hydration it helps keep things flowing. Here's my plan of action: (Due to my schedule I can only carve out 2 "time windows.") The Simvastatin should not have had a major effect either way on your BP it is a cholesterol med a Statin, not a BP med. For infections: Adults and teenagers300 milligrams (mg) every twelve hours or 600 mg once a day, taken for 5 to 10 days. I take 5mg rosuvastatin and coq10 ubiquinol. If this was me (not medical advice), Ivermectin, lumbrokinase, serrapeptase, CDS, EPA fish oil, quercetin or rutin, l-citrulline, magnesium glycinate possibly internal DMSO but consulting a doctor for this serious situation is a must. Letting food be your medicine always seems to work better than tablets or capsules. I would hate to be taking unnecessary supplements. I refused taking Eliquis or Warfarin, after a ton of reading much to my Doctor's anger. I wonder, did you tell your doctors about all the stuff you are taking? I was maintained an Plavix following the stroke with no side effects. Is it safe to add Lumbrokinase to the mix or should I alternate every few weeks? Brought in all of my supplements, D-Ribose, CoQ10, nattokinase, cholesterol complete, Mag, taurine, etc., neither one of them would even look at the bottles. 307 (Pt 2): 331333. While there is still some debate as to whether PQQ can be considered a vitamin or not, this compound is certainly necessary for many enzymes working in the body. Nutrients 2021;13(6):2031. Gallelli G, Di Mizio G, Palleria C, et al. All Please note Im not too bothered about taking it for blood clotting issues even though I do have a post-viral chronic illness that came along before covid, Yes, IMO, taking nattokinase with food pretty much turns it into a digestive enzyme and cancels out most or all of its intended benefits. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Since her stroke, she now reluctantly takes a proven atrial fibrillation blood thinner. My batch quantities of 700g of natto are easily made and last for 7 days in the refrigerator, providing my wife and I the ability to eat (and thoroughly enjoyi) at least 50g of homemade natto a day. I think Nattokinase would be fine and effective but I prefer taking lumbrokinase and serrapeptase instead Lumbrokinase is a far stronger clot (fibrin) dissolver than nattokinase but either way should be effective. Hope that helps! https://www.medindia.net/news/healthwatch/soft-or-hard-plaque-which-poses-greater-risk-of-heart-attack-168735-1.htm. Hi, Kat, I think the only thing in your heal n soothe that thins blood is ginger. While the Japanese eat it every morning over rice with mustard, soy sauce, or other flavorings, I just eat it plain. In East Asia, natto has been popular for thousands of years. It works by killing bacteria. I until recently drank a glass of red wine with lunch 6-8oz only. Sometimes, people with chronic sinusitis may need surgery to clear nasal passages.. Attach lids firmly and (wearing safety I have worked in Natural Health field for many years. Start with 1 capsule of Serrapeptase twice a day, well away from meals. Got tachy cardia from htz because cant keep hydrated because any liquid I drink is quickly removed. We actually sell a form of serrapeptase that is not and it is highly effective. I am a big fan of the enzymes discussed here and also a substance called Chlorine Dioxide Solution (CDS) Look up a video by Dr. kalcker, the foremost expert on CDS called "CDS for newbies". I think that helped, perhaps a lot. My blood pressure is also high. Quercetin is a good supplement, but gives me side effects. I recommend not taking them at the same time all such enzymes as nattokinase should be taken on an empty stomach alone. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. I have developed a DVT to the left of mt kneewith discolouration circuling my knee. Indeed, studies show that Japanese eating the most natto have the lowest rates of heart disease and strokes. The problem with atrial fibrillation strokes is that it takes a powerful blood thinner to prevent them. While there arent a lot of studies on nattokinase and inflammation levels, of the studies that do exist nattokinase may function as a natural anti-inflammatory agent. "Personally, I would not combine LK with NK but would take serrapeptase with either." Problem is he refuses to give up his 6 oz. Combined nattokinase with red yeast rice but not nattokinase alone has potent effects on blood lipids in human subjects with hyperlipidemia. #262 Is Nattokinase the Safest Blood Thinner? I am very familiar with proteolytic enzymes but I have personally not tried them up until a month ago. View abstract. An individual that is looking to take a, relevant directions on product labels, and consult your pharmacist, physician or other. Japanese restaurants do have the aquired taste Natto but call to make sure. Thus, if it takes megadoses of nattokinase to have the same blood thinning effect as less than a half of a baby aspirin, this probably explains why I couldnt find any significant reports from nattokinase in the studies I reviewed. It can also help lower your blood pressure, reducing strain on the heart that can lead to heart attacks. My doctor put me HCTZ 12.5mg and Simvastatin 20mg. While the nattokinase enzyme is derived from a food, it is best taken away from food (on an empty stomach) when it is in supplement form. View abstract. I also worry about the purity of any supplement. Dr. Day, The Profibrinolytic Enzyme Subtilisin NAT Purified from Bacillus subtilis Cleaves and Inactivates Plasminogen Activator InhibitorType 1. I was recently diagnosed with Afib and have had one additional episode over a 5 month period of time. For those not familiar with vitamin K2, vitamin K2 helps to keep calcium out of your arteries and into your bones where it belongs. Is there any negative to taking this in a fasted state? Apart from those obvious drawbacks, soybean natto has an omega-3 to omega-6 ratio of more than 7, making it inflammatory. I've also had one heart attack resulting in a stent. When it comes to enzymes, your body is going to use what it needs and then flush the rest. VERY concerned perhaps a combo of LK and Serrapeptase would be appropriate for you, a Naturopathic MD knowledgeable about these enzymes would be a worthy investment. It may solve a lot of problems but do your homework and consult with good people!! Most Asian grocery stores carry fresh natto. I also have a zero Calcium CT score, at least back in '17 maybe time for another. Now I`m wondering can the particles in the Diatomaceous earth harm the enzymes? Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Whats the effective dose of Nattokinase to dissolve block clots and fibrin? Nattokinase may thin the blood and help break up blood clots. In addition to fibrinogen and factors VII and VIII, another study showed that nattokinase also works on platelets. Interestingly, some studies show that it is only fermented soy that offers any of these benefits. Thank you so much. If you are interested I could PM you his story. I've been in the healthcare field for some 27 years with a specialty in clinical exercise physiology and functional integrative medicine. Most of my heart patients are scared to death of blood thinners. Real Happiness. This information may not fit your specific health circumstances. Potential Dangers and Side Effects. Is this due to the spike protein and what is that relationship to clotting? Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Perhaps his stroke was "provoked" and the risk is now gone? If possible, natto should be aged in fridge for minimum of 3 4 days before (However, S. boullardii, a probiotic strain recommended by the AGA for C . Now, my cardiologist is recommending I take Xeralto. Ten years ago, I was in a car crash which nearly took my life. When you take a nattokinase supplement, you dont get the probiotics and you dont get vitamin K2 either. Hemorrhoid sufferers will be glad to know that nattokinase works for hemorrhoids since hemorrhoids are a type of varicose vein. In the nattokinase group, plaque size decreased by 36.6%. Based on ultrasound imaging after their long airplane flight, none of the people taking nattokinase suffered a blood clot. Cefdinir may also interfere with urine glucose or ketone tests. These small commissions help us to partially pay for the costs of maintaining a website, newsletter, and podcast. many thanks. I do not recommend MMS at all. Couple of points: 1. Two common anti-platelet drugs are aspirin and Plavix (clopidogrel). Today, many grocery stores and specialty health food shops worldwide sell natto. View abstract. One possible explanation may be natto. Nattokinase is an enzyme extracted from traditional Japanese fermented soybeans and has been shown to an effective enzyme in improving various hypercoagulation-associated parameters; it looks very promising as an oral enzyme in the treatment and prevention of cardiovascular diseases. Soy Products. When I first tried natto, Ill admit I was grossed out. Select a condition to view a list of vitamins. Maybe I will get brave and try it with my eyes closed and a clothes pin on my nose. Foods 2021;10(7):1558. DMSO is said ti be a strong clot-buster in its own right. I have taken for a month+ and it has helped a lot, and no side effects. Asia Pac J Clin Nutr 2009;18(3):310-7. 7-12-2003; Pais, E., Alexy, T., Holsworth, R. E., Jr., and Meiselman, H. J. NATTOKINASE. Take this medication by mouth with or without food as directed by your doctor, usually once or twice daily. Good Health Naturally 2000 FU Delayed Release. Both are said to help to thin blood. Thanks for telling us about it. For those of you not familiar with fibrinogen, factor VII, or factor VIII, let me explain. High blood pressure is a major medical problem as it leads to heart attacks, strokes, kidney failure, blindness, and dementia. Unfortunately, most "mainstream" MDs know nothing of enzymes like Nattokinase or serrapeptase. Until a nattokinase longevity study is done, the best data we have are from the natto eating Japanese population. Experientia 1987;43:1110-1. careful if you are on blood thinners Although natto can be made with black beans, adzuki beans, kidney beans and even sunflower seeds, the bacteria used to make it thrives best on soybeans, which help produce nattokinase more efficiently.It is important to note that nattokinase is not found in other non-fermented soy foods, which makes the distinction between natto and unfermented, genetically modified soy very clear. I've also had friends who have serious side effects from the vax. I took up to two 20mg Lumbrokinase (Blouoke brand) three time/day and 80,000 SPU of Serrapeptase daily always on empty stomach and waited 30-60 minutes after before eating. I can answer general health questions and will do my best to answer your questions in my blogs, podcasts, or videos. Natto, in turn, is made from fermenting soybeans with the helpful bacteria called Bacillus natto. If he (and you) are vaxxed the clotting risk rises significantly, from all that I have read so taking either the nattokinase or a prescription blood thinner might be even more important is it possible the stroke was a vaxx side effect? Platelets can clump together in your blood which can be the start of a blood clot. In your resurch have you found any efforts being made to make Natto more palatable, I have read that Natto is positively disgusting. For oral dosage forms (capsules or suspension): For infections: Adults and children 15 years of age and older1000 to 4000 milligrams (mg) per day, taken in divided doses. 6 Nattomotto (Natto Spores) 0.12g $1.46 The articles below may make you feel better, they did me. I have a family history of heart disease and a coronary calcium scan show some build up on the left side. The reason why it is sticky and slimy is that it is a probiotic. Angiology 2003;54:531-9. A Pyrex jug filled with boiling water does just fine. Currently taking Nattokinase in am empty stomach and 60000 serrapeptase daily. Research suggests that supplement intake is just as effective as consuming natto. Cureus 2021;13(12):e20074. I know you are not a doctor as I am just looking for another opinion. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Nattokinase is generally safe, but the enzymes potent effects may cause complications for people with certain health conditions. If you are a worm, nattokinase will help you live an extra six days. Chronic sinusitis is ongoing inflammation in your sinuses that could be caused by allergies, bacteria, fungal infections, or asthma. JMHO, Thank you for your comments Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. First Im glad I found you. BTW: Are you scared of having your BP taken now? This sure is getting to be a long thread!! Right now Im taking 2000 fu in the morning. Hi JJ, Thank you. "About 300-times stronger than serrapeptase, an enzyme extracted from silkworms. However, there are two things to note when doing this. I also take 4 g fish oil, 2400 mg garlic extract, 200 IU Vitamin E, 240 mg ginkgo biloba per day away from nattokinase . Any thoughts please? Had the stroke in April 2022 and it basically effected coordination on my right side. Because I want to keep my body in a state of natural balance, this is another reason why I prefer natto over the nattokinase supplement. Nattokinase may just be the safest blood thinner you have never heard of. You can read more about it here: My DVT was lower leg and was quite long. Suzuki Y, Kondo K, Ichise, H, et al. Cerebral infarction, myocardial infarction, and other diseases generally occur in the morning, so it is recommended that everyone should take nattokinase after dinner at night, the effect is more obvious. I have to keep my pressure under control because I have high pressure in my eye, for which I use eyedrops. 67mg of d alpha tocopherol succinate. WebMD does not provide medical advice, diagnosis or treatment. Rinse soaked soy beans, beluga and barley until water runs clear, 3. Even though it smells like a dead rat what bothers me the most is how slimy and sticky it is. Now that he's off blood thinner & aspirin, we are trying nattokinaise. This might protect against heart disease and. When researching how these supplements should be taken, I read Lumbrokinase is best in morning and Nattokinase us best at night. Japan uses nature appropriately. Sumi H, Hamada H, Tsushima H, et al. Nattokinase has powerful effects on your health, including: Studies show that nattokinase dissolves blood clots which helps maintain good blood vessel structure, improves blood flow, and lowers the risk of heart disease. One study shows that a nattokinase supplement lowers the risk of blood clots after long plane. All rights reserved. Dietary supplementation with fermented soybeans suppresses intimal thickening. 1 capsule of NAC twice a day is best taken 15 minutes before eating with a full glass of water. My husband had a ischemic stroke recently. Sorry inflammation is indicated by the C-RP and homocysteine tests, cholesterol levels are indicated by the usual tests. 5 Soya Beans Organic 8g $0.04 I think everyone should hold off on Ivermectin alone and especially with nattokinase, or K2/Mk-7 or quercetin. View abstract. All rights reserved. Nattokinase atherothrombotic prevention study: A randomized controlled trial. My philosophy on supplements is that a supplement should be a supplement. View abstract. It did lower my numbers but not to within the normal range. When it comes to staying young and healthy, you want to keep inflammation levels as low as possible. And if you havent read it yet, pick up your copy now to find out why this best selling book has consistently maintained a 4.9-star rating on Amazon! I am unvaxed. maybe ask for a Lipo(a) blood test, if that is low good stuff seems like you are doing fine, adding some LK would not hurt only help JMHO BTW, don't ever rely on MY opinions ;-). Awful side effects. I am not aware of any interactions between the two. IMOI think Nattokinase is supposed to be taken on an empty stomach, otherwise it becomes an expensive digestive enzyme fasting means empty stomach, so no problem. container vents open (or lids ajar) to allow any remaining condensation to escape, 15. Thanks for any feedback! Of all the bad things that atrial fibrillation can cause, strokes have to be at the top of the list. My older three children wont go near the stuff. For humans, we really dont know if nattokinase increases longevity or not. Taking both ok? amount of boiling water to each bowl. 1 Lentils Black Beluga Organic 212g $1.48 Intern Med 2008;47(5):467-469. My CRP is 2.97. View abstract. Redfood's Nattokinase 2000 FU. But that was then and back then I knew NOTHING of serrapeptase nor nattokinase. Sterilize inner bowls by adding small Biochem. Yes I do have a kickass naturopath ever since I got my DVT last March. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Anecdotally, I have seen a stroke in one of my atrial fibrillation patients who faithfully took her nattokinase. Serrapeptase is a fantastic enzyme to be supplementing for pain and inflammation issues. I prefer lumbrokinase as it's : Pour inoculant culture equally over each batch of natto in yogurt bowls and stir However, studies have reported several side effects in people . Real Food. So that is why I am taking the the Heal & soothe. This online natto was shipped over ice. Every time I have been vaccinated my d dimer goes up which is terrifying. With this being said, the best time to take nattokinase is on an empty stomach, and preferably with at least 8 ounces of water .. An encapsulated supplement can take anywhere from 15-45 minutes to make its way through the stomach, depending on the individual person. Thanks for all of your helpful comments. In one study, researchers wanted to find out how nattokinase and aspirin compared. Hope that helps and makes sense. I also take quercetin, vitamin d, methyl, resveratrol, ginkgo biloba, a multivitamin, glutathione, burdock root, and NAC- does this all seem like too much? Serrapeptase does thin blood, but much less than nattokinase. I don't take nattokinase because it gives me some side effects, probably because it comes from fermented substance and I have histamine intolerance issues perhaps you do too. 1 in a.m & 2 bedtime. It works by killing bacteria or preventing their growth. can you e-mail me back. So I stopped taking anything, except Hawthorn Blend. He took a prescription blood thinner for 90 days along with aspirin. Do you agree? Not medical advice but I ran across some info that is a bit alarming.
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